Embiid, who previously missed Monday's game with a right sinus fracture, helped the Sixers take advantage of a depleted Charlotte Hornets roster.
The 76ers welcomed back Joel Embiid Friday night and the Hornets were without several key pieces due to injuries.
As expected, the Sixers took advantage of that in a 108-98 victory at the Wells Fargo Center.
Embiid, donning a mask, finished with game highs of 34 points and nine assists after missing Monday's game against the Hornets because of a right sinus fracture.
The victory improved the Sixers to 9-16 and marked their sixth victory in eight games. Philly also swept this season's four games against the Hornets (7-21), extending their series winning streak to 10 games. The team has also won 27 of its last 29 meetings.
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Charlotte was without All-Star LaMelo Ball (left calf injury management), Brandon Miller (sprained left ankle), Marc Williams (left foot injury management), Tre Mann (disc irritation) and Grant Williams (right ACL tear).
But the Hornets made things closer than expected.
The Sixers saw a commanding 23-point cushion dwindle down to four points with 6 minutes, 56 seconds remaining. After the teams traded baskets, the Sixers went on a 5-0 run, which included Guerschon Yabusele posterizing a Hornet, to build a 96-87 advantage.
Embiid scored 12 of his points in the third quarter before adding 12 in the fourth quarter. None of those fourth-quarter points were bigger than his three straight baskets to give the Sixers a 102-94 lead with 3:54 left.
Tyrese Maxey had 23 points, six assists and four rebounds. Kelly Oubre Jr. added 22 points while making 4 of 6 three-pointers. Paul George has 10 rebounds, eight assists and three steals. However, he only had five points while making just 2 of 12 shots. George missed six of seven three-pointers.
The Sixers finished with a season-high 30 assists. Vasilije Micic, who started at point guard in place of Ball, led the Hornets with 20 points.
The Sixers will head to Cleveland after Friday's game for a Saturday matchup with the Cavaliers at the Rocket Mortgage Fieldhouse.
The Cavs took a league-best 23-4 record into Friday's home game against the Milwaukee Bucks. Saturday's matchup will be the second of three meetings between the Sixers and the Cavs.
Cleveland held on to defeat the Sixers, 114-106, on Nov. 13. Rookie guard Jared McCain, who is now out indefinitely with a left meniscus tear, finished with a career-high of 34 points in his first career start.
The Sixers were without their All-Star trio of Maxey (strained right hamstring), Embiid (left knee injury management) and George (left knee injury management) for that game.